#Liquid chl skin

Animal experiments showed that CHL could significantly alleviate the levels of inflammatory factors and TLR4/NF-κB/p38 MAPK signaling pathway in acne. The CHL was significantly associated with ten pathways including the Chagas disease and pathways in cancer. The biological processes were primarily related to cellular response to lipid, response to lipopolysaccharide, and regulation of secretion. This approach identified 165 active compounds, 1117 gene targets, 156 acne-related targets, and 34 potential target proteins for the treatment of acne with CHL. Finally, the results were further verified by establishing the mouse acne animal model. TCM-compound-target-disease network and disease-target pathway network were constructed using Cytoscape to give the visual result. Gene Ontology (Go) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed on Metascape platforms and. Protein-Protein interaction (PPI) analysis was proceeded through String database to obtain the core protein, and the protein interaction network was constructed by Cytoscape 3.9.1. Venn diagrams to predict potential targets for the treatment of acne.

The target genes related to acne were extracted from GeneCards, DisGeNet and OMIM databases.

In this study, active components and action targets of Compound Huangbai Liquid were assessed via BATMAN-TCM. However, a holistic network pharmacological approach to explain the mechanism of CHL in the treatment of acne has not been explored. Compound Huangbai Liquid (CHL) is a classical traditional Chinese medicine (TCM) with remarkable clinical therapeutic effects on acne.

#Liquid chl skin

Acne is a highly prevalent skin disease, and inflammation plays an important role.